Two adjustable parameters related to the short-range interactions on the variable and constant regions were determined by fitting experimental data of 20 IgG1 monoclonal antibodies at 150 mg/mL. B 2018, 122, 2867–2880) was applied to study antibody interactions. In this work, a 12-bead coarse-grained model based on Swan and coworkers (J. Coarse-grained models, on the other hand can do this.
Molecular simulation is a promising method to study protein–protein interactions however, all-atom models do not allow the simulation of multiple molecules, which is necessary to compute viscosity directly.
The viscosity is determined by protein–protein interactions among many antibodies. High viscosity presents a challenge for manufacturing and drug delivery of therapeutic antibodies.
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